Case Report - Hypersensitivity and dose related side effects of phenytoin mimicking critical illness

OBJECTIVE: To describe phenytoin-induced rare hypersensitivity and dose related reactions, emphasizing the importance of early omission of drug to achieve clinical improvement. DESIGN: Case series and review of literature. SETTING: Tertiary level medical intensive care unit. PATIENTS: Three cases, t...

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Bibliographic Details
Published in:Indian journal of critical care medicine 2006-01, Vol.9 (1)
Main Author: Pillai LalithaV, Ambike DhananjayP, Hussainy SM K, Vishwasrao Sunil, Pataskar Satish, Gaikwad MarutiM
Format: Article
Language:English
Subjects:
Phenytoin, skin lesion, allergic alveolitis, dyskinesia, Phenytoin hypersensitivity syndrome (PHS)
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Summary:OBJECTIVE: To describe phenytoin-induced rare hypersensitivity and dose related reactions, emphasizing the importance of early omission of drug to achieve clinical improvement. DESIGN: Case series and review of literature. SETTING: Tertiary level medical intensive care unit. PATIENTS: Three cases, two of whom had hypersensitivity reactions and the third had drug-induced dyskinesia. INTERVENTION: Omission of phenytoin and corticosteroid therapy in two cases. RESULTS: Improvement and discharge. CONCLUSION: A high index of suspicion of drug-induced complications is necessary especially when multiple drugs are being administered to critically ill patients.
ISSN:0972-5229