Methotrexate toxicity presenting as ulceration of psoriatic plaques: A report of two cases

We describe two cases of methotrexate toxicity occurring due to inappropriate self-medication with the drug. The first patient was a 57-year-old man with plaque-type psoriasis on intermittent methotrexate therapy. He discontinued his medications for 2 months and had exacerbation of psoriasis for whi...

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Bibliographic Details
Published in:Indian journal of dermatology, venereology, and leprology venereology, and leprology, 2009-10, Vol.74 (5)
Main Authors: Agarwal, Kishan Kumar, Nath, Amiya Kumar, Thappa, Devinder Mohan
Format: Article
Language:English
Subjects:
Methotrexate toxicity, Psoriasis, Skin ulceration
Online Access:Get full text
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Summary:We describe two cases of methotrexate toxicity occurring due to inappropriate self-medication with the drug. The first patient was a 57-year-old man with plaque-type psoriasis on intermittent methotrexate therapy. He discontinued his medications for 2 months and had exacerbation of psoriasis for which he self-medicated with methotrexate following which he developed ulceration of the psoriatic plaques accompanied by bone marrow suppression. The second patient was a 68-year-old man with chronic plaque-type psoriasis for 20 years and was being treated with intermittent methotrexate for 15 years. He also self medicated with oral methotrexate 15 mg daily for 7 days for exacerbation of psoriasis and developed ulceration of the psoriatic plaques with bone marrow suppression and evidence of gastrointestinal erosions.
ISSN:0378-6323