A new recurring chromosome 13 abnormality in two older patients with de novo acute myeloid leukemia: An Indian experience

We report here two cases of trisomy 13 in acute myeloid leukemia M1 subtype. short-term unstimulated bone marrow and peripheral blood lymphocyte culture showed 47, XY, +13 in all metaphase plates and trisomy 13 was confirmed with whole chromosome paint probes. Trisomy 13 in AML-M1 is a rare numerica...

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Bibliographic Details
Published in:Indian journal of human genetics 2010-06, Vol.15 (3)
Main Authors: Trivedi, P J, Patel, P S, Brahmbhatt, M M, Patel, B P, Gajjar, S B, Dalal, E N, Shukla, S N, Shah, P M, Bakshi, S R
Format: Article
Language:English
Subjects:
Acute myeloid leukemia-M1, recurrent, sole abnormality, trisomy 13
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Summary:We report here two cases of trisomy 13 in acute myeloid leukemia M1 subtype. short-term unstimulated bone marrow and peripheral blood lymphocyte culture showed 47, XY, +13 in all metaphase plates and trisomy 13 was confirmed with whole chromosome paint probes. Trisomy 13 in AML-M1 is a rare numerical abnormality. This is the first Indian report of sole trisomy 13 in AML-M1. Here, we present two cases of elder male patients, which may constitute a distinct subtype.
ISSN:0971-6866