Loading…

Anti-Oxidant Protective Effects of Cassia alata in Rats Exposed to Carbon Tetrachloride

The protective activity of Cassia alata against carbon tetrachloride (CCl4) - induced hepatotoxicity in rats was assessed. Crude extracts of petals of the plant in 0.5% ethanol were administered by intubation for 14 days prior to injection of 0.5ml Kg-1 CCl4 into the rats. Serum aspartate aminotrans...

Full description

Saved in:
Bibliographic Details
Published in:Journal of applied science & environmental management 2005-12, Vol.9 (3)
Main Authors: WEGWU, M O, AYALOGU, E O, SULE, O J
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The protective activity of Cassia alata against carbon tetrachloride (CCl4) - induced hepatotoxicity in rats was assessed. Crude extracts of petals of the plant in 0.5% ethanol were administered by intubation for 14 days prior to injection of 0.5ml Kg-1 CCl4 into the rats. Serum aspartate aminotransferase and alanine aminotransferase levels, 18 hours after CCl4 administration, decreased significantly (P ≤ 0.05) in rats treated with the extracts than in CCl4 - treated rats only. These findings suggest that Cassia alata may be protective against hepatotoxin-induced liver damage in rats.@JASEM
ISSN:1119-8362