SHORT COMMUNICATION - Perspective of a New Diagnostic for Human Trichomonosis

Several diagnostic techniques have been employed for the detection of Trichomonas vaginalis . Microtubules constitute the cytoskeleton in eukaryotic cells and are sensitive to antimitotic drugs, such as Taxol (paclitaxel). We used FLUTAX a fluorescent taxoid - to analyze the microtubule distribution...

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Bibliographic Details
Published in:Memórias do Instituto Oswaldo Cruz 2003-04, Vol.98 (2)
Main Authors: Sheila B Lecke, Tiana Tasca, André A Souto, Geraldo A De Carli
Format: Article
Language:English
Subjects:
Trichomonas vaginalis - diagnostic techniques - FLUTAX
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Summary:Several diagnostic techniques have been employed for the detection of Trichomonas vaginalis . Microtubules constitute the cytoskeleton in eukaryotic cells and are sensitive to antimitotic drugs, such as Taxol (paclitaxel). We used FLUTAX a fluorescent taxoid - to analyze the microtubule distribution in living trophozoites of T. vaginalis in urine and in vaginal discharge. A high intensity of fluorescence was observed in living T. vaginalis , epithelial cells and leukocytes present in urine and vaginal discharge. Our preliminary results show the perspective of a new diagnostic technique for trichomonosis and will contribute to the understanding of the cytoskeleton of T. vaginalis .
ISSN:1678-8060