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Multiple cytokine expression profiles reveal immune-based differences in occult hepatitis B genotype H-infected Mexican Nahua patients
A high prevalence of occult hepatitis B (OHB) genotype H infections has been observed in the native Mexican Nahua population. In addition, a low incidence of hepatitis B virus(HBV)-associated hepatocellular carcinoma has been described in Mexico. The immune response to infection among OHB-infected p...
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Published in: | Memórias do Instituto Oswaldo Cruz 2012-07, Vol.106 (8) |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | A high prevalence of occult hepatitis B (OHB) genotype H infections has
been observed in the native Mexican Nahua population. In addition, a
low incidence of hepatitis B virus(HBV)-associated hepatocellular
carcinoma has been described in Mexico. The immune response to
infection among OHB-infected patients has been poorly evaluated in
vivo. Therefore, we assessed the expression profiles of 23 cytokines in
OHB genotype H-infected Nahua patients. A total of 41 sera samples from
natives of the Nahua community were retrospectively analysed. Based on
their HBV antibody profiles, patients were stratified into two groups:
OHB patients (n = 21) and patients that had recovered from HBV
infection (n = 20). Herein, we report distinctive cytokines profiles in
OHB-infected individuals. Compared to healthy controls (n = 20) and
patients who resolved HBV infection, OHB-infected patients displayed an
increase in interleukin (IL)-2 secretion in addition to a
characteristic inflammation profile (decrease in IL-8 and tumour
necrosis factor-alpha levels and increased levels of tumour growth
factor-beta). IL-15 and interferon-gamma levels were reduced in
OHB-infected individuals when compared to those patients who resolved
HBV infection. In contrast, OHB patients showed an increase in monocyte
chemoattractant protein (MCP)-1 and MCP-2 compared to healthy controls
and patients who resolved HBV infection. These findings suggest that
cytokine expression can influence the severity of OHB disease and could
lead to new investigation into the treatment of liver and other
infectious diseases. |
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ISSN: | 1678-8060 |