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Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon
The molecular basis of Plasmodium vivax chloroquine (CQ) resistance is still unknown. Elucidating the molecular background of parasites that are sensitive or resistant to CQ will help to identify and monitor the spread of resistance. By genotyping a panel of molecular markers, we demonstrate a simil...
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Published in: | Memórias do Instituto Oswaldo Cruz 2015-01, Vol.109 (7) |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | The molecular basis of Plasmodium vivax chloroquine (CQ) resistance is
still unknown. Elucidating the molecular background of parasites that
are sensitive or resistant to CQ will help to identify and monitor the
spread of resistance. By genotyping a panel of molecular markers, we
demonstrate a similar genetic variability between in vitro CQ-resistant
and sensitive phenotypes of P. vivax parasites. However, our studies
identified two loci (MS8 and MSP1-B10) that could be used to
discriminate between both CQ-susceptible phenotypes among P. vivax
isolates in vitro. These preliminary data suggest that microsatellites
may be used to identify and to monitor the spread of P.
vivax-resistance around the world. |
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ISSN: | 1678-8060 |