RESEARCH NOTE - IgE and IgG4 Antibodies in Subjects Reinfected with Schistosoma mansoni in an Endemic Area of Northeast Brazil

Analysis of the immune response of resistant and susceptible subjects in endemic areas indicated that resistance was associated with enhanced anti-parasite-IgE levels and that reinfection occurred when patients were producing high levels of antibodies that could compete with IgE. The results of thes...

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Bibliographic Details
Published in:Memórias do Instituto Oswaldo Cruz 1998-12, Vol.93
Main Authors: Yara M Gomes, Felipe C Gomes, Veridiana C Furtado, Kirte M Teixeira, Wayner V Souza, Frederico GC Abath
Format: Article
Language:English
Subjects:
schistosomiasis - IgE and IgG4 antibodies - Schistosoma mansoni
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Summary:Analysis of the immune response of resistant and susceptible subjects in endemic areas indicated that resistance was associated with enhanced anti-parasite-IgE levels and that reinfection occurred when patients were producing high levels of antibodies that could compete with IgE. The results of these reinfection studies suggest that acquired immunity develops slowly with age and that, although other factors can not be excluded, IgE specific antibodies play an important role in anti-schistosome resistance.
ISSN:1678-8060