Education Forum-Curcumin: A natural antiinflammatory agent

Extensive scientific research on curcumin, a natural compound present in the rhizomes of plant Curcuma longa   Linn., demonstrated its antiinflammatory action. Curcumin was found to inhibit arachidonic acid metabolism, cyclooxygenase, lipoxygenase, cytokines (Interleukins and tumour necrosis factor)...

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Bibliographic Details
Published in:Indian journal of pharmacology 2005-07, Vol.37 (3)
Main Author: Kohli K, Ali J, Ansari MJ, Raheman Z
Format: Article
Language:English
Subjects:
Cyclo-oxygenase (COX)
free radical scavenger
inflammation
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Summary:Extensive scientific research on curcumin, a natural compound present in the rhizomes of plant Curcuma longa   Linn., demonstrated its antiinflammatory action. Curcumin was found to inhibit arachidonic acid metabolism, cyclooxygenase, lipoxygenase, cytokines (Interleukins and tumour necrosis factor) Nuclear factor-kB and release of steroidal hormones. Curcumin was reported to stabilize lysosomal membrane and cause uncoupling of oxidative phosphorylation besides having strong oxygen radical scavenging activity, which was responsible for its antiinflammatory property. In various animal studies, a dose range of 100-200 mg/kg body weight exhibited good antiinflammatory activity and seemed to have negligible adverse effect on human systems. Oral LD50 in mice was found to be more than 2.0 g/kg body weight.
ISSN:0253-7613