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Development and evaluation of mucoadhesive chlorhexidine tablet formulations
Purpose: To formulate mucoadhesive chlorhexidine tablets and evaluate their drug release characteristics and mechanism. Methods: Chlorhexidine buccal adhesive tablets were prepared by direct compression using a blend of hydroxypropyl methylcellulose (HPMC) and chitosan as the bioadhesive polymers. T...
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Published in: | Tropical journal of pharmaceutical research 2011-03, Vol.9 (4) |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | Purpose: To formulate mucoadhesive chlorhexidine tablets and evaluate
their drug release characteristics and mechanism. Methods:
Chlorhexidine buccal adhesive tablets were prepared by direct
compression using a blend of hydroxypropyl methylcellulose (HPMC) and
chitosan as the bioadhesive polymers. Their dissolution properties were
assessed according to USP 24 (paddle method). In order to determine the
mode of drug release from the tablets, the release data were subjected
to various release kinetic models. The bioadhesive strength of the
tablets was also evaluated. Results: The results showed that as the
proportion of HPMC in the blend increased, drug release rate decreased,
with the lowest release rate observed when HPMC alone was used as the
bioadhesive polymer (p < 0.001). Both the type and ratio of the
polymers used influenced release kinetics. Also, bioadhesion force
increased with increasing proportion of HPMC in the tablets, with the
highest adhesion force shown when HPMC was the only polymer used, and
lowest when chitosan was used alone (p < 0.01). Conclusion: The
chlorhexidine formulations developed showed promise as a bioadhesive
delivery system for the drug. |
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ISSN: | 1596-5996 |