Clinical efficacy of radiotherapy combined with sodium glycididazole in the treatment of recurrent oesophageal carcinoma

Purpose: To assess the clinical efficacy and side effects of radiotherapy combined with sodium glycididazole in the treatment of recurrent esophageal carcinoma. Methods: Ninety patients with locally recurrent oesophageal carcinoma who were admitted to the Oncology Department at Taian City Central Ho...

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Bibliographic Details
Published in:Tropical journal of pharmaceutical research 2019-07, Vol.15 (12)
Main Authors: Jiao, Yu-Yan, Shen, Yu-Zhen, Liu, Yan, Yan, Hua, Wang, Jing, Li, Jian-Zhe
Format: Article
Language:English
Subjects:
Alopecia
Leucopaenia
Oesophageal carcinoma
Radiotherapy
Sodium glycididazole
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Summary:Purpose: To assess the clinical efficacy and side effects of radiotherapy combined with sodium glycididazole in the treatment of recurrent esophageal carcinoma. Methods: Ninety patients with locally recurrent oesophageal carcinoma who were admitted to the Oncology Department at Taian City Central Hospital, Shandong, China, were randomly divided into a treatment group (treated with radiotherapy and sodium glycididazole) and a control group (treated with radiotherapy alone) in a randomized study. Short-term curative effects, median progression-free survival (PFS), and side effects were compared between the two groups. Results: The cure rate in the treatment group was 86.70 %, whereas that in the control group was 51.10 % (p < 0.05). Median PFS in the treatment group was 9.9 months versus 5.3 months in the control group (p < 0.05). Side effects in both groups included alopecia, headache, nausea, vomiting and leucopaenia, at level one or two. In this regard, the difference between the two groups was statistically insignificant (p > 0.05). Conclusion: Radiotherapy combined with sodium glycididazole shows a higher short-term curative effect in the treatment of recurrent oesophageal carcinoma than radiotherapy alone.
ISSN:1596-5996