Clinical aspects associated with syndromic forms of Orofacial Clefts in a Colombian population

• Published in: Colombia médica (Cali, Colombia) Colombia), 2016-07, Vol.46 (4)
• Main Authors: Urueña, Liliana Arias, Balcazar, Ignacio Briceño, Lozano, Julio Martinez, Collins, Andrew, Patiño, Daniel Alfredo Uricoechea
• Format: Article
• Language: English
• Subjects: Cleft lip and palate, preeclampsia, aarskog-scott syndrome, congenital hip dysplasia; Labio hendido, fisura del paladar, preeclampsia, síndrome de Aarskog-scott, luxacion congénita de la cadera
• ISSN: 0120-8322

Objectives: To present descriptive epidemiology of Orofacial Clefts and to determine the association of syndromic forms with antenatal high-risk conditions, preterm birth, and comorbidities among nestedseries of cases. Methods: A study of nested-series of cases was conducted. Frequencies of cleft type, associated congenital anomalies, syndromic, non-syndromic and multiple malformation forms, and distribution of Orofacial Clefts according to sex and affected-side were determined. Odds ratios were calculated as measures of association between syndromic forms and antenatal high-risk conditions, preterm birth and comorbidities. A total of three hundred and eleven patients with Orofacial Clefts were assessed in a 12-month period. Results: The most frequent type of Orofacial Clefts was cleft lip and palate, this type of cleft was more frequent in males, whereas cleft palate occurred more often in females. The most common cases occurred as non-syndromic forms. Aarskog-Scott syndrome showed the highest frequency amongst syndromic forms. Hypertensive disorders in pregnancy, developmental dysplasia of the hip, central nervous diseases and respiratory failure showed significant statistical associations (p