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Inhibition Of Microsomal Lipid Peroxidation And Protein Oxidation By Extracts From Plants Used In Bamun Folk Medicine (Cameroon) Against Hepatitis
The antioxidant activities of 53 medicinal plants used in Bamun Folk Medicine for the management of jaundice and hepatitis were investigated. The studies were done using rat hepatic microsomes for lipid peroxidation and bovine serum albumin (BSA) for carbonyl group formation. Silymarine was used as...
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Published in: | African journal of traditional, complementary, and alternative medicines complementary, and alternative medicines, 2009-01, Vol.5 (3) |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | The antioxidant activities of 53 medicinal plants used in Bamun Folk
Medicine for the management of jaundice and hepatitis were
investigated. The studies were done using rat hepatic microsomes for
lipid peroxidation and bovine serum albumin (BSA) for carbonyl group
formation. Silymarine was used as reference compound. Fifteen different
extracts were effective at a dose of 200µg/ml in both experiments.
Specifically, 25 extracts inhibited lipid peroxidation initiated
non-enzymatically by ascorbic acid while 18 inhibited peroxidation as
determined by reduced Nicotinamide Adenine Dinucleotide Phosphate
(NADPH). The inhibitory concentration 50 (IC50) of 23 different plant
extracts was lower than 200µg/ml in the microsomal lipid
peroxidation inhibition study. Fifteen of the 23 extracts were active
in preventing protein oxidation by inhibiting the formation of the
carbonyl group on BSA with an IC50 value less than 200µg/ ml. The
results suggest that the antioxidant activity of the extracts, may be
due to their ability to scavenge free radicals involved in microsomal
lipid peroxidation or in protein oxidation. These biochemical processes
are involved in the aetiology of toxic hepatitis. |
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ISSN: | 0189-6016 |