DIMETHOXYFLAVONE ISOLATED FROM THE STEM BARK OF STEREOSPERMUM KUNTHIANUM POSSESSES ANTIDIARRHOEAL ACTIVITY IN RODENTS

This study was undertaken to evaluate the antidiarrhoeal activity of 3, 7, 4/-trihydroxy-3/-(8//-acetoxy-7//-methyloctyl)-5, 6-dimethoxyflavone, a flavonoid isolated from the stem bark of Stereospermum kunthianum . The antidiarrhoeal activity was evaluated using rodent models with diarrhoea. The nor...

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Bibliographic Details
Published in:African journal of traditional, complementary, and alternative medicines complementary, and alternative medicines, 2014-07, Vol.10 (4)
Main Authors: Ching, F. P, Otokiti, I.O, Egert-omoneukanrin, B
Format: Article
Language:English
Subjects:
antidiarrhoeal activity
Dimethoxyflavone
flavonoid
Stereospermum kunthianum
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Summary:This study was undertaken to evaluate the antidiarrhoeal activity of 3, 7, 4/-trihydroxy-3/-(8//-acetoxy-7//-methyloctyl)-5, 6-dimethoxyflavone, a flavonoid isolated from the stem bark of Stereospermum kunthianum . The antidiarrhoeal activity was evaluated using rodent models with diarrhoea. The normal intestinal transit, castor oil-induced intestinal transit and castor oil- induced diarrhoea tests in mice as well as castor oil-induced intestinal fluid accumulation in rats were employed in the study. The animals were pretreated with distilled water (10 ml/kg for mice, 5 ml/kg for rats), dimethoxyflavone (25 mg/kg or 50 mg/kg), morphine (10 mg/kg), or indomethacin (10 mg/kg) before induction of diarrhoea with castor oil (0.2ml for mice and 2ml for rats). Dimethoxyflavone dose dependently and significantly reduced (P
ISSN:0189-6016