Focal Cerebral Ischemia Induces Alzheimer s Disease-like Pathological Change in Rats

The changes in the tau protein phosphorylation and expression of bcl-2,and bax in rat parietal cortex neurons after focal cerebral ischemia-reperfusion(I/R)were explored,and the relationship between the tau protein phosphorylation and the expression of bax or apoptosis was clarified in order to eluc...

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Bibliographic Details
Published in:Journal of Huazhong University of Science and Technology. Medical sciences 2010 (1)
Main Author: 王海均 赵洪洋 叶佑范 熊南翔 黄俊红 姚东晓 沈寅 赵心同
Format: Article
Language:English
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Summary:The changes in the tau protein phosphorylation and expression of bcl-2,and bax in rat parietal cortex neurons after focal cerebral ischemia-reperfusion(I/R)were explored,and the relationship between the tau protein phosphorylation and the expression of bax or apoptosis was clarified in order to elucidate the relationship between cerebral infarction and Alzheimer's disease.The rat focal cerebral I/R model was induced by occlusion of the right middle cerebral artery using the intraluminal suture method.The le...
ISSN:1672-0733
1993-1352