Implications of anti-parietal cell antibodiesand anti-Helioobacterpylori antibodies in histological gastritis and patient outcome

• Published in: World journal of gastroenterology : WJG 2005, Vol.11 (30), p.4715-4720
• Main Author: Ching-Chu Lo Ping-I Hsu Gin-Ho Lo Kwok-Hung Lai Hui-Hwa Tseng Chiun-Ku Lin Hoi-Hung Chan Wei-Lun Tsai Wen-Chi Chen Nan-Jing Peng
• Format: Article
• Language: English
• Subjects: 幽门螺杆菌; 抗细菌作用; 抗腔壁细胞
• ISSN: 1007-9327; 2219-2840

AIM： To develop a serum or histological marker for early discovery of gastric atrophy or intestinal metaplasia. METHODS： This study enrolled 44 patients with gastric adenocarcinoma, 52 patients with duodenal ulcer, 14 patients with gastric ulcer and 42 consecutive healthy adults as controls. Each patient received an endoscopy and five biopsy samples were obtained. The degrees of histological parameters of gastritis were categorized following the Updated Sydney System. Anti-parietal cell antibodies （APCA） and anti- Helicobacter pylori （ H pylori） antibodies （AHPA） were analyzed by immunoassays. Hpyloriinfection was diagnosed by rapid unease test and histological examination. RESULTS： Patients with gastric cancer and gastric ulcer are significantly older than healthy subjects, while also displaying higher frequency of APCA than healthy controls. Patients with positive APCA showed higher scores in gastric atrophy and intestinal metaplasia of corpus than patients with negative APCA. Patients with positive AHPA had higher scores in gastric atrophy, intestinal metaplasia, and gastric inflammation of antrum than those patients with negative AHPA. Elderly patients had greater prevalence rates of APCA. Following multivariant logistic regression analysis, the only significant risk factor for antral atrophy is positive AHPA, while that for corpus atrophy is positive APCA. CONCLUSION： The existence of positive APCA correlates with glandular atrophy in corpus and the presence of positive AHPA correlates with glandular atrophy in antrum. The existence of serum APCA and AHPA betokens glandular atrophy and requires further examination for gastric cancer.