Effect of SNC19/ST14gene overexpression on invasion of colorectal cancer cells

AIM： TO study the effect of SNC19/ST14gene overexpression on invasion in vitro of colorectal cancer cells. METHODS： The adhesion of SlVC19/ST14gene-transfected cells to ECM was measured by MTT assay. The cell movement was evaluated by wound healing assay. Cell invasion and migration were determined...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2005, Vol.11 (36), p.5651-5654
Main Author: Ke-Feng Ding Li-Feng Sun Wei-Ting Ge Han-Guang Hu Su-Zhan Zhang Shu Zheng
Format: Article
Language:English
Subjects:
SNC19基因
ST14基因
基因表达
直肠癌
结肠癌
肿瘤细胞
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Summary:AIM： TO study the effect of SNC19/ST14gene overexpression on invasion in vitro of colorectal cancer cells. METHODS： The adhesion of SlVC19/ST14gene-transfected cells to ECM was measured by MTT assay. The cell movement was evaluated by wound healing assay. Cell invasion and migration were determined by invasion assay in vitro. RESULTS： SNC19/ST14 gene overexpression could enhance invasion of colorectal cancer cells in vitro significantly and influence early cell adherence to ECM, but could not change cell movement significantly. CONCLUSION： SNC19/ST14 gene overexpression increases the local invasion of colorectal cancer cells in vitro. 2005 The WJG Press and Elsevier Inc. All rights reserved.
ISSN:1007-9327
2219-2840