Prognostic value of additional pathological variables for longterm survival after curative resection of rectal cancer

• Published in: World journal of gastroenterology : WJG 2006, Vol.12 (28), p.4565-4568
• Main Author: Bojan Krebs Miran Kozelj Rajko Kavalar Borut Gajzer Eldar M Gadzijev
• Format: Article
• Language: English
• Subjects: 手术切除术; 生存质量; 病理学; 直肠癌
• ISSN: 1007-9327; 2219-2840

AIM： To evaluate the prognostic value of some pathological variables in rectal cancer survival. METHODS： 247 patients who underwent curative resection of rectal cancer were included in the study. The influence on survival of five pathological variables （histopathological tumor type, histopathological tumor grade differentiation, blood vessel invasion, perineural invasion and lymphatic invasion） was assessed using statistical analyses. RESULTS： Overall 5-year survival was 71.2%. Univariate analysis of all tested variables showed an effect on survival but only the effect of lymphatic invasion was statistically significant. At stages three and four it had a negative effect on survival （P = 0.0212）. Lymphatic invasion also significantly affected cancer related survival in multivariate analysis at stages three and four. At lower stages （stage 0, stage 1 and stage 2） multivariate analysis showed a negative effect of perineural invasion on cancer related survival. CONCLUSION： Patients with lymphatic and perineural invasion have a higher risk for rectal cancer related death after curative resection. Examination of these variables should be an important step in detecting patients with a poorer prognosis.