Crohn＇s disease： Innate immunodeficiency

In the past, Crohn＇s disease （CD） has been understood primarily as an immunologic disorder characterized by an abnormal T-cell response. Recent in vitro and in vivo data suggests that CD may instead be precipitated by innate immune dysfunction resulting from a combination of genetic and environmenta...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2006, Vol.12 (42), p.6751-6755
Main Author: Jesus K Yamamoto-Furusho Joshua R Korzenik
Format: Article
Language:English
Subjects:
免疫机制
结肠疾病
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Summary:In the past, Crohn＇s disease （CD） has been understood primarily as an immunologic disorder characterized by an abnormal T-cell response. Recent in vitro and in vivo data suggests that CD may instead be precipitated by innate immune dysfunction resulting from a combination of genetic and environmental factors. Some reports have demonstrated a defective immune response in a variety of other cellular components, including neutrophils, monocytes and dendritic cells. Recent studies of granulocyte-macrophage colony-stimulating factor （GM-CSF） in CD, aiming to stimulate the innate immune system with the conception that an innate immune defect underlies the development of the disease, have been demonstrated a clinical benefit and reinforce this evolving understanding of the disease.
ISSN:1007-9327
2219-2840