Quasi-physical Algorithm for Protein Folding in an Off-Lattice Model

We study a three-dimensional off-lattice protein folding model, which involves two species of residues interacting through Lennard-Jones potentials. By incorporating an extra energy contribution into the original potential function, we replace the original constrained problem with an unconstrained m...

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Bibliographic Details
Published in:Communications in theoretical physics 2007-01, Vol.47 (1), p.181-185
Main Authors: Zhi-Peng, Lü, Wen-Qi, Huang, He, Shi
Format: Article
Language:English
Subjects:
三维点阵模型
准物理算法
折叠结构
蛋白质
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Summary:We study a three-dimensional off-lattice protein folding model, which involves two species of residues interacting through Lennard-Jones potentials. By incorporating an extra energy contribution into the original potential function, we replace the original constrained problem with an unconstrained minimization of a mixed potential function. As such an efficient quasi-physical algorithm for solving the protein folding problem is presented. We apply the proposed algorithm to sequences with up to 55 residues and compare the computational results with the putative lowest energy found by several of the most famous algorithms, showing the advantages of our method. The dynamic behavior of the quasi-physlcal algorithm is also discussed.
ISSN:0253-6102
DOI:10.1088/0253-6102/47/1/034