Creation and anti-cancer potency in HeLa cells of a novel chimeric toxin, HMGNCIDIN, composed of HMGN2 α- helical domain and PE38 KDEL domain

Using targeted toxins is a promising approach for the therapy of cancer and autoimmune diseases, as well as other disorders/The high mobility group chromosomal protein N2 （HMGN2） is one of the most abundant and well-characterized classes of nonhistone nuclear proteins, which seems to function as arc...

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Bibliographic Details
Published in:Chinese medical journal 2008 (1), p.82-85
Main Author: XIONG Wen-bi HUANG Ning FENG Yun WU Qi WANG Bo-yao
Format: Article
Language:English
Subjects:
假单胞菌
医学实验
外毒素
肿瘤嵌合体
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Summary:Using targeted toxins is a promising approach for the therapy of cancer and autoimmune diseases, as well as other disorders/The high mobility group chromosomal protein N2 （HMGN2） is one of the most abundant and well-characterized classes of nonhistone nuclear proteins, which seems to function as architectural elements in chromatin.2 Recently our group isolated an antimicrobial polypeptide from human LAK cells and cervical mucus,
ISSN:0366-6999
2542-5641