lmpact of alanyl-glutamine dipeptide on severe acute pancreatitis in early stage

• Published in: World journal of gastroenterology : WJG 2008, Vol.14 (3), p.474-478
• Main Author: Ping Xue Li-Hui Deng Qing xia Zhao-Da Zhang Wei-Ming Hu Xiao-Nan Yang Bing Song Zong-Wen Huang
• Format: Article
• Language: English
• Subjects: 临床研究; 急性胰腺炎; 治疗方法
• ISSN: 1007-9327; 2219-2840

AIM： TO evaluate the therapeutic effect of alanyl-glutamine dipeptide （AGD） in the treatment of severe acute pancreatitis （SAP） in early and advanced stage. METHODS： Eighty patients with SAP were randomized and received 100 mL/d of 20% AGD intravenously for 10 d starting either on the day of （early treatment group） or 5 d after （late treatment group） admission. Groups had similar demographics, underlying diseases, Ranson score, Acute Physiology and Chronic Health Evaluation Ⅱ （APACHE Ⅱ） score, and Balthazar＇s computed tomography （CT） score at the beginning of the study and underwent similar other medical and nutritional management. RESULTS： The duration of acute respiratory distress syndrome （2.7±3.3d vs 12.7±21.0d, P 〈 0.01）, renal failure （1.3±0.5 d vs 5.3±7.3 d, P 〈 0.01）, acute hepatitis （3.2±2.3 d vs 7.0 ±7.1 d, P 〈 0.01）, shock （1.7±0.4 d vs 4.8±3.1 d, P 〈 0.05）, encephalopathy （2.3±1.9 d vs 9.5±11.0 d, P 〈 0.01） and enteroparalysis （2.2±1.4 d vs 3.5±2.2 d, P 〈 0.01） and hospital stay （28.8±9.4 d vs 45.2±27.1 d, P 〈 0.01） were shorter in the early treatment group than in the late treatment group. The 15-d APACHE Ⅱ score was lower in the early treatment group than in the late treatment group （5.0±2.4 vs 8.6±3.6, P 〈 0.01）. The infection rate （7.9% vs 26.3%, P 〈 0.05）, operation rate （13.2% vs 34.2%, P 〈 0.05） and mortality （5.3% vs 21.1%, P 〈 0.05） in the early treatment group were lower than in the late treatment group.CONCLUSION： Early treatment with AGD achieved a better clinical outcome in SAP patients.