Protective Role of Salidroside against Aginq in A Mouse Model Induced by D-galactose

• Published in: Biomedical and environmental sciences 2010 (2), p.161-166
• Main Author: GEN-XIANG MAO HONG-BIN DENG LONG-GUO YUAN DIAN-DONG LI YI-YANG YVONNE LI ZHEN WANG
• Format: Article
• Language: English
• Subjects: 保护作用; 半乳糖; 小鼠模型; 淋巴细胞增殖; 白细胞介素-2; 红景天甙; 胶质纤维酸性蛋白
• ISSN: 0895-3988; 2214-0190

Objective To investigate the protective effects of putative AGEs （advanced glycation endproducts） inhibitor salidroside against aging in an accelerated mouse aging model induced by D-galactose. Methods A group of 5-month-old C57BL/6J mice were treated daily with D-galactose, D-galactose combined with salidroside, salidroside alone, and control buffer for 8 weeks. At the end of the treatment, serum AGEs levels, neurological activities, expression of glial fibrillary acidic protein （GFAP） and neurotrophin-3 （NT-3） in the cerebral cortex, as well as lymphocyte proliferation and IL-2 production were determined. Results D-galactose induced mouse aging model was developed as described before. As expected, salidroside blocked D-galactose induced increase of serum AGEs levels. It also reversed D-galactose induced aging effects in neural and immune system, as evidenced by improving motor activity, increasing memory latency time, and enhancing lymphocyte mitogenesis and interleukin-2 （IL-2） production. Furthermore, elevated expression of GFAP and NT-3 in the aged model mice was also reduced upon salidroside treatment. Conclusion Salidroside inhibits AGEs formation in vivo, which at least partially contributes to its anti-aging effect in D-galactose induced aging model.