Allele polymorphisms of interleukin-lO and hepatitis B, C virus infection

• Published in: Chinese medical journal 2010, Vol.123 (10), p.1338-1344
• Main Author: LU Yong-liang WU Xiao HUANG Hui-lian DAI Li-cheng
• Format: Article
• Language: English
• Subjects: 专用软件; 丙型肝炎病毒; 乙型肝炎病毒; 乙肝病毒; 敏感性分析; 病毒感染; 白细胞介素10; 等位基因多态性
• ISSN: 0366-6999; 2542-5641

Background Interleukin 10 （IL-10） is an important cytokine with anti-inflammatory, anti-immune and anti-fibrotic functions. This study aimed at evaluating the relationship between allele polymorphisms in the IL-10 promoter region and hepatitis B virus （HBV） or hepatitis C virus （HCV） infection. Methods The odds ratios （ORs） of IL-10 allele distributions in patients with HBV or HCV infection were analyzed against healthy controls. All the relevant studies in PubMed were identified, and poor qualified studies were excluded. The meta-analysis software REVMAN 4.2 was applied for investigating heterogeneity among individual studies and summarizing all the studies. The publication bias was also evaluated. Results This study demonstrated a significant association between the IL-10-592 A/C polymorphism and HBV infection in the Asian population under the overall effect size of allele A versus C. In our subgroup meta-analysis, we found a significant association of IL-10-592 A/C polymorphism to HCV infection susceptibility in Asian populations, although sensitivity analysis showed that the combined result was not associated with the worldwide population. Other IL-10 allele polymorphisms were not associated with HBV or HCV infection. Conclusion IL-10-592 A/C allele might be a risk factor for HBV or HCV in Asians but not in Europeans.