Epistatic effect between A CA CA and FABP2 gene on abdominal fat traits in broilers

Epistasis is generally defined as the interaction between two or more genes or their mRNA or protein products to influence a single trait. Experimental evidence suggested that epistasis could be important in the determination of the genetic architecture of complex traits in domestic animals. Acetyl-...

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Bibliographic Details
Published in:Journal of genetics and genomics 2010 (8), p.505-512
Main Author: Guo Hu Shouzhi Wang Jianwei Tian Lili Chu Hui Li
Format: Article
Language:Chinese
Subjects:
CA
上位性效应
乙酰辅酶A羧化酶
单核苷酸多态性
基因遗传
肉鸡
脂肪性状
腹部
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Summary:Epistasis is generally defined as the interaction between two or more genes or their mRNA or protein products to influence a single trait. Experimental evidence suggested that epistasis could be important in the determination of the genetic architecture of complex traits in domestic animals. Acetyl-coenzyme A carboxylase alpha （ACACA） and fatty acid binding protein 2 （FABP2） are both key factors of lipogenesis and transport. They may play a crucial role in the weight variability of abdominal adipose tissue in the growing chicken. In this study, the polymorphisms of c.2292G〉A in A CA CA and c.-561A〉C in FABP2 were detected among individuals from two broiler lines which were divergently selected for abdominal fat content. Epistasis between the two SNPs on abdominal fat weight （AFW） and ab- dominal fat percentage （AFP） was analyzed. The additive x additive epistatic components between these two SNPs were found significant or suggestively significant on both AFW and AFP in lean lines of the 9th and 10th generatio
ISSN:1673-8527