Asymmetric hydrogenation of aromatic ketones using new chiral-bridged diphosphine/diamine-Ru（Ⅱ） complexes

A series of chiral secondary alcohols were easily prepared by means of asymmetric hydrogenation of prochiral aromatic ketones using a new（（Rax）-BuP）/（R,R）-DPEN-Ru（Ⅱ） complex catalyst system.The hydrogenation of 2-methylacetophenone in n-butanol （t-BuOK/Ru =45.6/1,S/C = 500,20 atm.of H2,20℃,48 h） aff...

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Bibliographic Details
Published in:Chinese chemical letters 2010 (12), p.1403-1406
Main Author: Yu Ming Cui Lai Lai Wang Fuk Yee Kwong Wei Sun
Format: Article
Language:English
Subjects:
不对称加氢
不对称氢化反应
催化剂体系
手性膦
自动取款机
芳香酮
苯乙酮
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Summary:A series of chiral secondary alcohols were easily prepared by means of asymmetric hydrogenation of prochiral aromatic ketones using a new（（Rax）-BuP）/（R,R）-DPEN-Ru（Ⅱ） complex catalyst system.The hydrogenation of 2-methylacetophenone in n-butanol （t-BuOK/Ru =45.6/1,S/C = 500,20 atm.of H2,20℃,48 h） afforded（S）-1-（2＇-methylphenyl）ethanol in 92%ee and〉99% conversion.
ISSN:1001-8417
1878-5964