Synthesis and anti-TMV activity of novel N-（pyrimidin-5-yl）-N1-phenylureas

In order to find novel leading structures of pesticide, a series of N-（pyrimidin-5-yl）-N1-phenylureas （4a-4h） were designed and synthesized from 4-chloro-2-diethylamino-6-methyl-5-nitropyrimidine 1 via substitution, reduction and acylation procedures. Preliminary bioassay showed that all the target...

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Bibliographic Details
Published in:Chinese chemical letters 2011, Vol.22 (1), p.18-20
Main Author: De Kai Yuan Da Qiang Zhang Ru Xing Li Dao Quan Wang Xin Ling Yang
Format: Article
Language:English
Subjects:
二乙氨基
化合物
抗烟草花叶病毒活性
活性测试
病毒唑
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Summary:In order to find novel leading structures of pesticide, a series of N-（pyrimidin-5-yl）-N1-phenylureas （4a-4h） were designed and synthesized from 4-chloro-2-diethylamino-6-methyl-5-nitropyrimidine 1 via substitution, reduction and acylation procedures. Preliminary bioassay showed that all the target compounds processing good anti-TMV （tobacco mosaic virus） activity. Two compounds （4d and 4e） displayed higher activity superior to virazole at a concentration of 5.0 ×10^-4 g/mE.
ISSN:1001-8417
1878-5964