Synthesis of 3,5-Dichloro-4-（1,1,2,2-tetrafluoroethoxy）phenyl Containing 1,2,3-Thiadiazole Derivatives via Ugi Reaction and Their Biological Activities

A series of novel 3,5-dichloro-4-（1,1,2,2-tetrafluoroethoxy）phenyl containing 4-methyl-l,2,3-thiadiazole derivatives were designed and synthesized via Ugi reaction. Their structures were confirmed by IR, 1H NMR, 13C NMR and high-resolution mass spectroscopy. The preliminary bioassay results indicate...

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Bibliographic Details
Published in:Chinese journal of chemistry 2011, Vol.29 (2), p.288-296
Main Author: Wang Shouxin Wang Huan Fan Zhijin Fu Yifeng Mi Na Zhang Jufang Zhang Zhengcai Belskaya Nataliya P. Bakulev Vasiliy A
Format: Article
Language:English
Subjects:
Ugi反应
反应合成
噻二唑衍生物
标题化合物
烟草花叶病毒
生物活性
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Summary:A series of novel 3,5-dichloro-4-（1,1,2,2-tetrafluoroethoxy）phenyl containing 4-methyl-l,2,3-thiadiazole derivatives were designed and synthesized via Ugi reaction. Their structures were confirmed by IR, 1H NMR, 13C NMR and high-resolution mass spectroscopy. The preliminary bioassay results indicated that some title compounds had good fungicide activity at 50 ug/mL; most of the compounds presented a certain degree of direct inhibition activity, good inactivation and curative activity against tobacco mosaic virus at 500 ug/mL and 100 ug/mL; some compounds showed good larvicidal activity against Plutella xylostella L. at 200 ug/mL and excellent larvicidal activities against Culex pipiens pallens at 2 ug/mL.
ISSN:1001-604X
1614-7065