Spectrophotometric Determination of Albendazole Drug in Tablets： Spectroscopic Characterization of the Chargetransfer Solid Complexes

• Published in: Chinese journal of chemistry 2011, Vol.29 (2), p.324-332
• Main Author: Refat Moamen S Mohamed Gehad G. Fathi Ahmed
• Format: Article
• Language: English
• Subjects: 光度法测定; 光谱表征; 共轭亚油酸; 固体配合物; 实验条件; 桑德尔灵敏度; 阿苯达唑
• ISSN: 1001-604X; 1614-7065

Simple, rapid and reliable method for the determination of albendazole （ABZ） was described. This includes the utility of some π-acceptors such as 2,3-dichloro-5,6-dicyano-p-benzoquinone （DDQ） and 3,6-dichloro-2,5-dihydroxy-p-benzoquinone （p-CLA） for estimation of ABZ drug （act as donor）. The experimental conditions were optimized and the system obeys Beer＇s law for 7.50-80 and 10.00-85.00 ug·mL-1 of ABZ using DDQ and p-CLA, respectively. The molar absorptivity and Sandell sensitivity were calculated to be 1.83× 10^3 and 1.12× 10^3 L·mol ·cm -1 and 2.60 and 3.40 ng·cm -2 using DDQ and p-CLA, respectively. The limits of detection and quantification were calculated to be （7.42 and 6.73） and （9.94 and 4.13） ug·mL-1 using DDQ and p-CLA, respectively. The proposed methods were successfully applied to the determination of ABZ in commercially available dosage forms. The reliability of the assays was established by parallel determination by the official method and recovery studies. The chemical structures of the solid charge-transfer （CT） complexes formed via reaction between ABZ under study and π-acceptors, have been elucidated using elemental analyses （C, H and N）, IR, 1H NMR and mass spectra.