Expressions of the γ2 chain of laminin-5 and secreted protein acidic and rich in cysteine in esophageal squamous cell carcinoma and their relation to prognosis

Previous studies have shown that the expressions of the γ2 chain of laminin-5 and secreted protein acidic and rich in cysteine （SPARC） play important roles in oncogenesis and the development of carcinoma. To assess the expressions of laminin-5 γ2 chain and SPARC in esophageal squamous cell carcinoma...

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Bibliographic Details
Published in:Ai zheng 2011, Vol.30 (1), p.69-78
Main Author: Li-Yan Xue Shuang-Mei Zou Shan Zheng Xiu-Yun Liu Peng Wen Yan-Ling Yuan Dong-Mei Lin Ning Lu
Format: Article
Language:Chinese
Subjects:
分泌蛋白
半胱氨酸
层粘连蛋白
蛋白表达
链表
预后
食管癌
鳞状细胞癌
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Summary:Previous studies have shown that the expressions of the γ2 chain of laminin-5 and secreted protein acidic and rich in cysteine （SPARC） play important roles in oncogenesis and the development of carcinoma. To assess the expressions of laminin-5 γ2 chain and SPARC in esophageal squamous cell carcinoma （SCC）, and to clarify the prognostic significance of the expressions of laminin-5 γ2 chain and SPARC in esophageal SCC, we detected the expressions of laminin-5 γ2 chain and SPARC in cancer tissue and corresponding normal mucosa from 116 patients with advanced （stages II-IV） esophageal SCC using the tissue microarray-based immunohistochemistry and analyzed the correlation of the expressions with clinicopathologic characteristics and survival. We found that in normal esophageal tissues, laminin-5 γ2 chain was expressed in the basement membrane, whereas in esophageal SCC tissues, laminin-5 γ2 chain was expressed in the cytoplasm of carcinoma cells, with a positive rate of 72.4%. SPARC was not detected in normal esop
ISSN:1000-467X
1944-446X