Bioinformatics analysis of breast cancer bone metastasis related geneCXCR4

Objective:To analyze breast cancer bone metastasis related gene-CXCR4.Methods:This research screened breast cancer bone metastasis related genes by high-flux gene chip.Results:It was found that the expressions of 396 genes were different including 165 up-regulations and 231 down-regulations.The expr...

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Published in:亚太热带医药杂志：英文版 2013 (9), p.732-738
Main Author: Heng-Wei Zhang Xian-Fu Sun Ya-Ning He Jun-Tao Li Xu-Hui Guo Hui Liu
Format: Article
Language:English
Subjects:
analysis
Bioinformatics
bone
Breast
cancer
CXCR4
metastasis
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Summary:Objective:To analyze breast cancer bone metastasis related gene-CXCR4.Methods:This research screened breast cancer bone metastasis related genes by high-flux gene chip.Results:It was found that the expressions of 396 genes were different including 165 up-regulations and 231 down-regulations.The expression of chemokine receptor CXCR4 was obviously upregulated in the tissue with breast cancer bone metastasis.Compared with the tissue without hone metastasis,there was significant difference,which indicated that CXCR4 played a vital role in breast cancer bone metastasis.Conclusions:The hioinformatics analysis of CXCR4 can provide a certain basis for the occurrence and diagnosis of breast cancer bone metastasis,target gene therapy and evaluation of prognosis.
ISSN:1995-7645
2352-4146