Comparison of trabeculectomy and trabeculectomy with amniotic membrane transplantation in the same patient with bilateral glaucoma

• Published in: 国际眼科杂志：英文版 2013 (4), p.448-451
• Main Author: Qing-Shan Ji Bing Qi Lian Liu Wei Lao Zhi-Hao Yang Gui-Fang Wang Guo-Cheng Yu Jing-Xiang Zhong
• Format: Article
• Language: English
• Subjects: amniotic; glaucoma; membrane; trabeculectomy; transplantation
• ISSN: 2222-3959; 2227-4898

· AIM: To observe effects of trabeculectomy with amniotic membrane transplantation (AMT) in controlling postoperative intraocular pressure (IOP) in patients with medically uncontrolled glaucoma. ·METHODS: This study included adult patients with requiring bilateral glaucoma surgery. Each patient underwent trabeculectomy (Non-AMT group) in one eye and with AMT (AMT group) in the other eye according to randomized principle. Success was defined as intraocular pressure (IOP) <21mmHg without any anti -glaucoma medications at 24 months follow -up. The two groups were compared in terms of IOP, complications and success rate. · RESULTS: Thirty -four eyes of 17 patients were investigated in this study. There was no statistically signifcant difference in pre -operative IOP between the two groups. The mean IOP was lower in AMT group compared with Non-AMT group on follow up months 12, 18, and 24. Postoperative complications were more frequent in Non-AMT group (35.3% , 6/17) compared with AMT group (5.9%, 1/17). The success rate of surgery was 88.2% (15/17) in Non -AMT group and 100% (17/17) in AMT group. · CONCLUSION: Trabeculectomy with AMT is an effective procedure to reduce IOP and complications, thereby improving surgical success rates.