Plasma coenzyme Q10 levels in type 2 diabetic patients with retinopathy

· AIM: To determine the relationship between proliferative diabetic retinopathy (PDRP) and plasma coenzyme Q10 CoQ10 concentration. ·METHODS: Patients with type 2 diabetes and PDRP were determined to be the case group ( =50). The control group was consist of healthy individuals ( =50). Plasma CoQ10...

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Published in:国际眼科杂志:英文版 2013 (5), p.674-678
Main Author: Orhan Ates Habip Bilen Sadullah Keles H. Hakan Alp Mevlüt Sait Keles Kenan Yild■rum Osman ndas L. Can P■nar Mustafa Civelekler Orhan Baykal
Format: Article
Language:English
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Summary:· AIM: To determine the relationship between proliferative diabetic retinopathy (PDRP) and plasma coenzyme Q10 CoQ10 concentration. ·METHODS: Patients with type 2 diabetes and PDRP were determined to be the case group ( =50). The control group was consist of healthy individuals ( =50). Plasma CoQ10 and malondialdehyde (MDA) levels were measured in both groups. ·RESULTS:Ubiquinone-10(CoenzymeQ10)levelsinPDRP and control subjects are 3.81±1.19μmol/L and 1.91±0.62μmol/L, respectively. Plasma MDA levels in PDRP and control subjects were 8.16 ±2μmol/L and 3.44 ±2.08μmol/L, respectively. Ratio of Ubiquinol -10/ubiquinone -10 in PDRP and control subjects were 0.26±0.16 and 1.41±0.68, respectively. ·CONCLUSION: The ratio of ubiquinol-10/ubiquinone- 10 is found lower in patients with PDRP. High levels of plasma ubiquinol -10/ubiquinone -10 ratio indicate the protective effect on diabetic retinopathy. ·
ISSN:2222-3959
2227-4898