Loading…

A Randomized, Controlled, Double-Blinded and Double- Dummy Trial of the Effect of Tongjiang Granule (通降颗粒) on the Nonerosive Reflux Disease of and Gan (肝)-Wei (胃) Incoordination Syndrome

Objective: To assess the effectiveness of Tongjiang Granule (TJG, 通降颗粒) on the patients with nonerosive reflux disease (NERD) of Gan (肝)-Wei (胃) incoordination syndrome, its impact on their quality of life, and its safety. Method: A randomized, controlled, double-blinded, and double-dummy method was...

Full description

Saved in:
Bibliographic Details
Published in:中国结合医学杂志:英文版 2011, Vol.17 (5), p.339-345
Main Author: LI Bao-shuang LI Zhen-hua TANG Xu-dong ZHANG Li-ying ZHAO Zing-pan BIAN Li-qun ZHANG Yin-qiang WANG Ping WANG Feng-yun
Format: Article
Language:English
Subjects:
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective: To assess the effectiveness of Tongjiang Granule (TJG, 通降颗粒) on the patients with nonerosive reflux disease (NERD) of Gan (肝)-Wei (胃) incoordination syndrome, its impact on their quality of life, and its safety. Method: A randomized, controlled, double-blinded, and double-dummy method was adopted in the trial. There were 120 NERD patients enrolled in the study and randomly divided into the experiment and control groups, each with 60 patients; drugs were distributed according to the drug number by patients' inclusion sequences. In the experiment group, patients were given TJG 10 g and mosapdde citrate dummy 5 mg three times a day, and in the control group, patients were given mosapdde citrate 5 mg and TJG dummy 10 g three times a day. The treatment courses of both groups were 4 weeks. Results: Among 120 included patients, 112 were screened for full analysis set (FAS), and 105 were screened per-protocol set (PPS). The results were as follows: (1) the improvement of total scores of symptom in the experiment group (0-4 week) were 15.93 ± 7.88 scores by FAS and 16.22 ±7.75 scores by PPS, and they were 10.43± 10.16 scores and 10.79± 10.27 scores in the control group, respectively. The 95% CI of net scores improvement between the two groups were 2.10- 8.90 scores and 1.92-8.94 scores in FAS and PPS; it was significantly better in the experiment group than that in the control group (P〈0.05). (2) The improvement of scores of major symptom in the experiment group (0-4 week) were 10.68±5.35 by FAS and 10.89±5.29 by PPS and 7.40±7.41 and 7.60±7.46 in the control group, respectively. The 95% CI of net scores improvement in the two groups were 0.85-5.71 and 0.71-5.69 in FAS and PPS separately, and the improvement in the experiment group was significantly better than that in the control group (P〈0.05). (3) The total effective rates were 86.0% and 61.8% in the experiment and the control group separately, and the Ridit analysis results showed that it was better in the experiment group (P〈0.05). (4) The improvement quality of life in the domain of physical functioning and general health in the experiment group was better than that in the control group (P〈0.05). (5) One case of experiment group caught a cold and recovered in six days without drug suspension. No adverse event was found in the other cases. There was no meaningful safety examination indices change in pretreatment and posttreatment periods in both groups. Conclusion: TJG showed a definite effect on th
ISSN:1672-0415
1993-0402