Current status of thiopurine analogues in the treatment in Crohn＇s disease

In the last decades,with the development of biological therapy,the treatment paradigms in patients with Crohn＇s disease have continuously evolved.Several studies focusing on the optimal use of both traditional immunosuppressants and biological therapy have been published,investigating conventional,a...

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Bibliographic Details
Published in:世界胃肠病学杂志：英文版 2011, Vol.17 (39), p.4372-4381
Main Author: Peter Laszlo Lakatos Lajos S Kiss
Format: Article
Language:English
Subjects:
免疫抑制剂
巯基嘌呤
患者
生物治疗
类似物
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Summary:In the last decades,with the development of biological therapy,the treatment paradigms in patients with Crohn＇s disease have continuously evolved.Several studies focusing on the optimal use of both traditional immunosuppressants and biological therapy have been published,investigating conventional,accelerated stepup and top-down approaches.In addition,much emphasis has been placed in recent years on the de-termination of important predictive factors that could enable early patient stratification,which would lead to a tailored management strategy.In this review,the authors try to highlight new evidence on the optimal timing,benefits,and risks of immunosupressants alone,or in combination,in patients with Crohn＇s disease.
ISSN:1007-9327
2219-2840