Nogo receptor 3, a paralog of Nogo-66 receptor 1 （NgR1）, may function as a NgR1 co-receptor for Nogo-66

Nogo-A is a major myelin associated inhibitor that blocks regeneration of injured axons in the central nervous system （CNS）. Nogo-66 （a 66-residue domain of Nogo-A） expressed on the surface of oligodendrocytes has been shown to directly interact with Nogo-66 receptor 1 （NgRI）. A number of additional...

Full description

Saved in:
Bibliographic Details
Published in:遗传学报 2011, Vol.38 (11), p.515-523
Main Author: Lei Zhang Xia Kuang Jian Zhang
Format: Article
Language:Chinese
Subjects:
NOGO
Nogo受体
中枢神经系统
信号机制
少突胶质细胞
结合活性
结合蛋白
表面表达
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nogo-A is a major myelin associated inhibitor that blocks regeneration of injured axons in the central nervous system （CNS）. Nogo-66 （a 66-residue domain of Nogo-A） expressed on the surface of oligodendrocytes has been shown to directly interact with Nogo-66 receptor 1 （NgRI）. A number of additional components of NgR1 receptor complex essential for its signaling have been uncovered. However, detailed composition of the complex and its signaling mechanisms remain to be fully elucidated. In this study, we show that Nogo receptor 3 （NgR3）, a paralog of NgRI, is a binding protein for NgR1. The interaction is highly specific because other members of the reticulin family, to which Nogo-A belongs, do not bind to NgR3. Neither does NgR3 show any binding activity with Nogo receptor 2 （NgR2）, another NgRI paralog. Majority of NgR3 domains are required for its binding to NgR1. Moreover, a truncated NgR3 with the membrane anchoring domain deleted can function as a decoy receptor to reverse neurite outgrowth inhibition ca
ISSN:1673-8527