Anchanling reduces pathology in a lactacystin-induced Parkinson＇s disease model

A rat model of Parkinson＇s disease was induced by injecting lactacystin stereotaxically into the left mesencephalic ventral tegmental area and substantia nigra pars compacta. After rats were intragastrically perfused with Anchanling, a Chinese medicine, mainly composed of magnolol, for 5 weeks, when...

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Published in:中国神经再生研究：英文版 2012, Vol.7 (3), p.165-170
Main Author: Yinghong Li Zhengzhi Wu Xiaowei Gao Qingwei Zhu Yu Jin Anmin Wu Andrew C. J.Huang
Format: Article
Language:English
Subjects:
乳
大鼠模型
定向诱导
帕金森氏症
帕金森病
病理
酪氨酸羟化酶
黑质致密部
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Summary:A rat model of Parkinson＇s disease was induced by injecting lactacystin stereotaxically into the left mesencephalic ventral tegmental area and substantia nigra pars compacta. After rats were intragastrically perfused with Anchanling, a Chinese medicine, mainly composed of magnolol, for 5 weeks, when compared with Parkinson’s disease model rats, tyrosine hydroxylase expression was increased, α-synuclein and ubiquitin expression was decreased, substantia nigra cell apoptosis was reduced, and apomorphine-induced rotational behavior was improved. Results suggested that Anchanling can ameliorate Parkinson＇s disease pathology possibly by enhancing degradation activity of the ubiquitin-proteasome system.
ISSN:1673-5374