Laterally Sandwich-typed Hydrogel Columns with Liner Poly（N- isopropylaerylamide） Layer： Preparation, Swelling/ deswelling Kinetics and Drug Delivery Characteristics

A novel thermo-responsive hydrogel column, featured with both ends of linear poly（N- isopropylacrylarnide） （PNIPAM） chains being grafted onto cross-linked PNIPAM chains, was reported. The laterally sandwich-typed hydrogel columns were fabricated by radical polymerization in a three-step process usin...

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Bibliographic Details
Published in:武汉理工大学学报：材料科学英文版 2012, Vol.27 (1), p.115-119
Main Author: 李莹 肖新才
Format: Article
Language:English
Subjects:
PNIPAM
凝胶柱
制备
夹心型
水凝胶
溶胀动力学
班轮
释药特性
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Summary:A novel thermo-responsive hydrogel column, featured with both ends of linear poly（N- isopropylacrylarnide） （PNIPAM） chains being grafted onto cross-linked PNIPAM chains, was reported. The laterally sandwich-typed hydrogel columns were fabricated by radical polymerization in a three-step process using a method of ice-melting synthesis. The initiating path, morphology and thermoresponsive characteristics of the prepared hydrogel columns were experimentally studied. The results show that the hydrogel column obtained by the initiator inside part has more quick swelling and deswelling rates responsing to temperature cycling than other hydrogels owing to linear PNIPAM chains to form supermacroporous structure. The proposed hydrogel structure provide a new mode of the phase transition behavior for thermo-sensitive ＂smart＂ or ＂intelligent＂ monodisperse micro-actuators, which is highly attractive for targeting drug delivery systems, chemical separations, and sensors and so on.
ISSN:1000-2413
1993-0437