β-Alanine-DBU＂ A Highly Efficient Catalytic System forKnoevenageI-Doebner Reaction under Mild Conditionsβ-Alanine-DBU＂ A Highly Efficient Catalytic System forKnoevenageI-Doebner Reaction under Mild Conditions

A mild and efficient Knoevenagel-Doebner reaction from malonic acid and a wide range of aldehydes was catalyzed by a catalytic system consisting offlalanine and 1,8-diazabicyclo[5.4.0]undec-7-ene （DBU）, affording the corresponding （E）-a,fl-unsaturated carboxylic acids in good to excellent yields and...

Full description

Saved in:
Bibliographic Details
Published in:中国化学：英文版 2012, Vol.30 (1), p.139-143
Main Author: 祝令建 雷宁 缪震元 盛春泉 庄春林 姚建忠 张万年
Format: Article
Language:English
Subjects:
Knoevenagel
不饱和羧酸
丙氨酸
催化系统
反应
氮杂双环
温和条件
高效催化
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A mild and efficient Knoevenagel-Doebner reaction from malonic acid and a wide range of aldehydes was catalyzed by a catalytic system consisting offlalanine and 1,8-diazabicyclo[5.4.0]undec-7-ene （DBU）, affording the corresponding （E）-a,fl-unsaturated carboxylic acids in good to excellent yields and with high stereoselectivity. The advantage of the method is that the reaction could proceed smoothly at ambient temperature so that it can tolerate a variety of functional groups and avoid unnecessary side reactions.
ISSN:1001-604X
1614-7065