Dectin- 1 isoforms contribute to distinct Th 1/Th 17 cell activation in mucosal candidiasis

• Published in: 中国免疫学杂志：英文版 2012, Vol.9 (3), p.276-286
• Main Author: Agostinho Carvalho Gloria Giovannini AntoneUa De Luca Carmen D＇Angelo Andrea Casagrande Rossana G Iannitti Giovanni Ricci Cristina Cunha Luigina Romani
• Format: Article
• Language: English
• Subjects: 亚型; 小鼠品系; 念珠菌; 粘膜免疫; 细胞免疫反应; 细胞因子; 细胞活化; 遗传背景
• ISSN: 1672-7681; 2042-0226

The recognition of p-glucans by dectin-1 has been shown to mediate cell activation, cytokine production and a variety of antifungal responses. Here, we report that the functional activity of dectin-1 in mucosal immunity to Candida albicans is influenced by the genetic background of the host. Dectin-1 was required for the proper control of gastrointestinal and vaginal candidiasis in C57BIJ6, but not BALB/c mice; in fact, the latter showed increased resistance in the absence of dectin-1. The susceptibility of dectin-l-deficient C57BL/6 mice to infection was associated with defects in IL-17A and aryl hydrocarbon receptor-dependent IL-22 production and in adaptive Th I responses. In contrast, the resistance of dectin- 1-deficient BALB/c mice was associated with increased IL-17A and IL-22 production and the skewing towards Thl/Treg immune responses that provide immunological memory. Disparate canonical/ noncanonical NF-KB signaling pathways downstream of dectin-1 were activated in the two different mouse strains. Thus, the net activity of dectin-1 in antifungal mucosal immunity is dependent on the host＇s genetic background, which affects both the innate cytokine production and the adaptive Th1/Th17 cell activation upon dectin-1 signaling.