Effect of chitosan/type I collagen/gelatin composites n biocompatibility and nerve repair

Chitosan, collagen I and gelatin were mixed in appropriate quantities to develop a new nerve repair material, with good arrangement and structure, as well as even aperture size. The composite material was sterilized by 60Co irradiation for 24 hours prior to implantation in the right thigh of rats fo...

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Bibliographic Details
Published in:中国神经再生研究：英文版 2012, Vol.7 (15), p.1179-1184
Main Author: Qing Wang Xiaolei Yang Ming Ren Yulin Hu Qiang Chen Lei Xing Chunyang Meng Tiemei Liu
Format: Article
Language:English
Subjects:
修复材料
型胶原
壳聚糖
复合材料
明胶
生物相容性
神经损伤
辐照灭菌
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Summary:Chitosan, collagen I and gelatin were mixed in appropriate quantities to develop a new nerve repair material, with good arrangement and structure, as well as even aperture size. The composite material was sterilized by 60Co irradiation for 24 hours prior to implantation in the right thigh of rats following sciatic nerve damage. Results showed that the material was nontoxic to the kidneys and the liver, and did not induce an inflammatory response in the muscles. The composite material enhanced the recovery of sciatic nerve damage in rats. These experimental findings indicate that the composite material offers good biocompatibility and has a positive effect on injured nerve rehabilitation.
ISSN:1673-5374