Investigating effects of nano-particles infiltrat

In this paper,we introduce our finding of the effects of C_（60） nanoparticles （NP） infiltration on mechanical properties of cell and its membrane.Atomic force microscopy （AFM） is used to perform indentation on both normal and C_（60） infiltrated red blood cells （RBC） to gain data of mechanical charac...

Full description

Saved in:
Bibliographic Details
Published in:中国科学：物理学、力学、天文学英文版 2012, Vol.55 (6), p.989-995
Main Author: ZHANG XiaoYue ZHANG Yong ZHENG Yue WANG Biao
Format: Article
Language:English
Subjects:
NPS
人红细胞膜
力学性能
原子力显微镜
机械特性
相互作用机制
红血细胞
纳米粒子
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this paper,we introduce our finding of the effects of C_（60） nanoparticles （NP） infiltration on mechanical properties of cell and its membrane.Atomic force microscopy （AFM） is used to perform indentation on both normal and C_（60） infiltrated red blood cells （RBC） to gain data of mechanical characteristics of the membrane.Our results show that the mechanical properties of human RBC membrane seem to be altered due to the presence of C_（60） NPs.The resistance and ultimate strength of the C_（60） infiltrated RBC membrane significantly decrease.We also explain the mechanism of how C_（60） NPs infiltration changes the mechanical properties of the cell membrane by predicting the structural change of the lipid bilayer caused by the C_（60） infiltration at molecular level and analyze the interactions among molecules in the lipid bilayer.The potential hazards and application of the change in mechanical characteristics of the RBCs membrane are also discussed.Nanotoxicity of C_（60） NPs may be significant for some biological cells.
ISSN:1674-7348
1869-1927