Antituberculosis and cytotoxic activities of triorganotin（IV） complexes

Five triorganotin（IV） （1-5） complexes of cinnamic acid, （Z）-2-acetamido-3-phenylacrylic acid, 3-methylbut-2-enoic acid, and 2,2-diphenylacetic acid have been synthesized and characterized by IH-13C-119Sn NMR, UV, and IR. The spectroscopic investigation demonstrated that the carboxylate group acts as...

Full description

Saved in:
Bibliographic Details
Published in:中国化学快报：英文版 2012, Vol.23 (6), p.731-735
Main Author: Hidayat Hussain NaziaBibi Ahmed Al-Harrasi Salman Siddiqi Shahana U. Kazmi Ying Zhang Amin Badshah
Format: Article
Language:English
Subjects:
乙酰氨基
二苯基乙酸
单齿配体
对数生长期
核磁共振
细胞毒活性
结核分枝杆菌
配合物
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Five triorganotin（IV） （1-5） complexes of cinnamic acid, （Z）-2-acetamido-3-phenylacrylic acid, 3-methylbut-2-enoic acid, and 2,2-diphenylacetic acid have been synthesized and characterized by IH-13C-119Sn NMR, UV, and IR. The spectroscopic investigation demonstrated that the carboxylate group acts as a monodentate ligand in triorganotin（IV） compounds. Five triorganotin（IV） complexes were screened against the log phase culture of Mycobacterium tuberculosis H37Rv by colorimetric method using XTT dye as growth indicator. The MICs were found to he 0.08 and 1.25μg/mL.
ISSN:1001-8417
1878-5964