Structural insights into DndE from Escherichia coil B7A involved in DNA phosphorothioation modification

Dear Editor, DNA phosphorothioate （PT） modification, originally developed as an artificial tool to stabilize oligodeoxynucleotides against nuclease degradation , was recently found to be incorporated with sulfur into DNA backbone as a novel physiological variation by the five-gene dnd cluster （dndA-...

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Bibliographic Details
Published in:细胞研究：英文版 2012, Vol.22 (7), p.1203-1206
Main Author: Wei Hu Chengkun Wang Jingdan Liang Tianlong Zhang Zhongpei Hu Zhijun Wang Wenxian Lan Fang Li Houming Wu Jianping Ding Geng Wu Zixin Deng Chunyang Cao
Format: Article
Language:English
Subjects:
DNA
修改
大肠杆菌
寡核苷酸
生理变化
磷酸酯
结构
酶降解
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Summary:Dear Editor, DNA phosphorothioate （PT） modification, originally developed as an artificial tool to stabilize oligodeoxynucleotides against nuclease degradation , was recently found to be incorporated with sulfur into DNA backbone as a novel physiological variation by the five-gene dnd cluster （dndA-dndE） products in a sequence- and stereo-specific manner .
ISSN:1001-0602
1748-7838