Synthesis and in vitro biological evaluation of famesylthiosalicylic acid derivatives as anti-tumor carcinoma agents

Novel farnesylthiosalicylic acid （PTA） derivatives 5a-m with different substituted 1,3,4-thiadiazoles were synthesized. Compounds 5b, 5e, 5e and 5f displayed anti-tumor activities superior to FTA in most cancer cells tested. Furthermore, 5e induced tumor cell apoptosis, which was accompanied by lowe...

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Bibliographic Details
Published in:中国化学快报：英文版 2012, Vol.23 (10), p.1141-1144
Main Author: Yong Ling You An Xiao Guang Tong Chen Dong Geng Wang Yu Qin Li Xin Yang Wang Heng Zheng
Format: Article
Language:English
Subjects:
caspase
体外
合成
噻二唑衍生物
抗肿瘤活性
生物评价
癌细胞
肿瘤细胞凋亡
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Summary:Novel farnesylthiosalicylic acid （PTA） derivatives 5a-m with different substituted 1,3,4-thiadiazoles were synthesized. Compounds 5b, 5e, 5e and 5f displayed anti-tumor activities superior to FTA in most cancer cells tested. Furthermore, 5e induced tumor cell apoptosis, which was accompanied by lower Bcl-2 expression, but with higher Bax and caspase 3 expression activities in cancer cells.
ISSN:1001-8417
1878-5964