Mutational analysis of KCNJll in Chinese elderly essential hypertensive patients

Objective To compare the distribution ofKCNJll polymorphisms between elderly Chinese population with and without hypertension. Methods We examined the mutation of KCNJll gene by directly sequencing. Data for the present study were obtained from 250 hypertensive subjects （60 to 83 years old） as well...

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Bibliographic Details
Published in:老年心脏病学杂志：英文版 2012, Vol.9 (2), p.153-157
Main Author: Jia-Yue Li Zong-Bin Li Mei Zhu Yu-Qi Liu Yang Li Shi-Wen Wang Qing-Lei Zhu
Format: Article
Language:English
Subjects:
中国人群
中老年人
原发性
多态性
序列变异
直接测序
突变分析
高血压患者
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Summary:Objective To compare the distribution ofKCNJll polymorphisms between elderly Chinese population with and without hypertension. Methods We examined the mutation of KCNJll gene by directly sequencing. Data for the present study were obtained from 250 hypertensive subjects （60 to 83 years old） as well as 250 normotensive subjects （60 to 86 years old）. Results We found nine different mutations in KCNJ11, including six novel mutations （1131M, L1471, L147V, L147L, Q235H, G245C）. None of the novel mutations were found in the normotensive subjects, and all the residues were conserved in other species. These sequence variants in Chinese population indicate the diversity of the human library and the complexity of hypertension. Conclusions The consistent finding of our present study provided a basis for the development of new strategies to diagnosis and treat hypertension in the elderly.
ISSN:1671-5411