yδ-T cells： an unpolished sword in human anti-infection immunity

yδ-T cells represent a small population of immune cells, but play an indispensable role in host defenses against exogenous pathogens, immune surveillance of endogenous pathogenesis and even homeostasis of the immune system. Activation and expansion of yδ-T cells are generally observed in diverse hum...

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Bibliographic Details
Published in:中国免疫学杂志：英文版 2013, Vol.10 (1), p.50-57
Main Author: Jian Zheng Yinping Liu Yu-Lung Lau Wenwei Tu
Format: Article
Language:English
Subjects:
T细胞亚群
免疫反应
免疫系统
免疫细胞
宿主防御
感染性疾病
抗感染免疫
糙米
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Summary:yδ-T cells represent a small population of immune cells, but play an indispensable role in host defenses against exogenous pathogens, immune surveillance of endogenous pathogenesis and even homeostasis of the immune system. Activation and expansion of yδ-T cells are generally observed in diverse human infectious diseases and correlate with their progression and prognosis, yδ-T cells have both ＇innate＇ and ＇adaptive＇ characteristics in the immune response, and their anti.infection activities are mediated by multiple pathways that are under elaborate regulation by other immune components. In this review, we summarize the current state of the literature and the recent advancements in yδ-T cell-mediated immune responses against common human infectious pathogens. Although further investigation is needed to improve our understanding of the characteristics of different yδ-T cell subpopulations under specific conditions, yδ-T cell-based therapy has great potential for the treatment of infectious diseases.
ISSN:1672-7681
2042-0226