A Case of Hepatitis B Reactivation in an Anti-HBs Positive, Anti-HBc Positive non-Hodgkin＇s Lymphoma Patient

Dear Editor, We report a case of HBV reactivation in an anti-HBs positive, anti-HBc positive non-Hodgkin＇s lymphoma patient. Hepatitis B virus （HBV） reactivation is a well-recognized complication of patients undergoing chemotherapy or immunosuppressive therapy for lymphomas. The presence of antibodi...

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Bibliographic Details
Published in:中国病毒学：英文版 2013 (1), p.49-52
Main Author: Chunchen Wu Hui Shi Mengji Lu Yang Xu Xinwen Chen
Format: Article
Language:English
Subjects:
乙型肝炎病毒
乙肝表面抗原
免疫抑制
患者
抗体阳性
淋巴瘤
金
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Summary:Dear Editor, We report a case of HBV reactivation in an anti-HBs positive, anti-HBc positive non-Hodgkin＇s lymphoma patient. Hepatitis B virus （HBV） reactivation is a well-recognized complication of patients undergoing chemotherapy or immunosuppressive therapy for lymphomas. The presence of antibodies to the hepatitis B surface antigen （anti-HBs） has been identified to be a factor preventing HBV reactivation in patients with occult HBV infection receiving chemotherapy. In this paper, we present a non-Hodgkin Lymphoma patient who, before immunosuppressive therapy, displayed positive anti-HBs and positive antibodies to hepatitis B core antigens （anti-HBc）, as markers of resolved HBV infection, and developed hepatitis B surface antigen （HBsAg） and high viraemia with an HBV escape mutant after rituximab- based administration.
ISSN:1674-0769
1995-820X