Perspective：Recent advances in the study of testicular nuclear receptor 4

Testicular nuclear receptor 4 （TR4）, also known as NR2C2 （nuclear receptor subfamily 2, group C, member 2）, is a transcriptional factor and a member of the nuclear receptor family. TR4 was initially cloned from human and rat hypothalamus, prostate, and testes libraries. For almost two decades, its s...

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Bibliographic Details
Published in:浙江大学学报：B卷英文版 2013, Vol.14 (3), p.171-177
Main Author: Xian-fan DING Shi-cheng YU Bi-de CHEN Shinojen LIN Chawnshang CHANG Gong-hui LI
Format: Article
Language:English
Subjects:
前列腺癌
动物技术
基因敲除
小鼠模型
染色体分配
核受体
睾丸
组织分布
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Summary:Testicular nuclear receptor 4 （TR4）, also known as NR2C2 （nuclear receptor subfamily 2, group C, member 2）, is a transcriptional factor and a member of the nuclear receptor family. TR4 was initially cloned from human and rat hypothalamus, prostate, and testes libraries. For almost two decades, its spe- cific tissue distribution, genomic organization, and chromosomal assignment have been well investi. gated in humans and animals. However, it has been very difficult to study TR4＇s physiological functions due to a lack of specific ligands. Gene knock-out animal techniques provide an alternative approach for defining the biological functions of TR4. In vivo studies of TR4 gene knockout mice （TR4-/-） found that they display severe spinal curvature, subfertility, premature aging, and prostate prostatic intraepithe. lial neoplasia （PIN） development. Upstream modu- lators, downstream target gene regulation, feedback mechanisms, and differential modulation mediated by the recruitment of other nuclear receptors and coregu｜ators have been identified in studies using the TR4-~- phenotype. With the establishment of a tissue-specific TR4-/- mouse model, research on ＂I＇R4 will be more convenient in the future.
ISSN:1673-1581
1862-1783