Synthesis of pyrazinyl compounds from glycerol and 1,2-propanediamine over Cu-TiO_2 catalysts supported on γ-Al_2O_3

Cu-TiO_2 catalysts supported onγ-Al_2O_3 are prepared and used in glycerol cyclization with 1,2-propanediamine to produce pyrazinyl compounds including 6-hydroxymethyl-2-methylpyrazine,5-hydroxymethyl -2-methyIpyrazine,2,6-dimethylpyrazine and 2,5-dimethylpyrazine in a fixed-bed system.It is found t...

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Bibliographic Details
Published in:中国化学快报：英文版 2013 (8), p.751-754
Main Author: Xue Li Cheng-Hua Xu Chuan-Qi Liu Yu Chen Jian-Ying Liu
Format: Article
Language:English
Subjects:
丙二胺
二氧化钛催化剂
二甲基吡嗪
化合物
合成
性能
环化反应
甘油
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Summary:Cu-TiO_2 catalysts supported onγ-Al_2O_3 are prepared and used in glycerol cyclization with 1,2-propanediamine to produce pyrazinyl compounds including 6-hydroxymethyl-2-methylpyrazine,5-hydroxymethyl -2-methyIpyrazine,2,6-dimethylpyrazine and 2,5-dimethylpyrazine in a fixed-bed system.It is found that glycerol cylclization with 1,2-propanediamine gave a high total yield of pyrazinyl compounds（〉80%） over Cu-Ti02/γ-Al_2O_3 catalyst,and cyclization was through the reactions between activated 1,2-propanediamine and the intermediates from glycerol dehydration and oxidation.In addition,the regioselectivity of the pyrazinyl compounds was mainly controlled by the steric hindrance of the substrates during the cyclization process.
ISSN:1001-8417
1878-5964